[dr Bogdan A. Solaja]

Telefon:   011-2638606, 011-3336750 (kabinet), 011-3336659 (lab.), 011-3336681 (lab)

Telefon (lokalni):   750 (kabinet), 659 (lab.), 681 (lab)

Kabinet:   433

Laboratorija:   432, 468

E-mail:   bsolaja@chem.bg.ac.rs

Lični podaci

Rođen 1951. u Beogradu, oženjen, troje dece.

Obrazovanje i usavršavanja

1970-1975: Osnovne studije - Hemijske nauke / Prirodno-matematički fakultet (Beograd)

1975-1978: Magistratura - Hemijske nauke / Prirodno-matematički fakultet (Beograd)

1978-1984: Doktorat - Hemijske nauke / Prirodno-matematički fakultet (Beograd)

1985-1987: Postdoktorske studije / Organisch Chemisches Institut der Universität Zürich (Zürich, Švajcarska)

Kretanje u službi

1976: Student saradnik / Prirodno-matematički fakultet (Beograd)

1978: Asistent pripravnik / Prirodno-matematički fakultet (Beograd)

1981: Asistent / Prirodno-matematički fakultet (Beograd)

1994: Docent / Univerzitet u Beogradu - Hemijski fakultet (Beograd)

1995: Vanredni profesor / Univerzitet u Beogradu - Hemijski fakultet (Beograd)

2001-2016: Redovni profesor / Univerzitet u Beogradu - Hemijski fakultet (Beograd)

2016-2017: Direktor Inovacionog centra / Inovacioni centar Hemijskog fakulteta u Beogradu, d.o.o.

Oblasti naučnog interesovanja

Organska hemija: sinteza, ispitivanje mehanizama i nove reakcije; sintetičke aplikacije organoaluminijumovih jedinjenja.

Medicinska hemija: tetraoksacikloheksani – antimalarijsko i antitumorsko dejstvo i osobine; hloraminohinolini - antimalarijsko dejstvo i inhibicija botulinum toksina; steroidni hinoni i njihovi derivati - antitumorsko dejstvo.

Nagrade i priznanja

1993: Zaslužni član Srpskog hemijskog društva

8. 12. 2009: Počasni član Srpskog hemijskog društva

3. 12. 2015: Medalja za trajan i izvanredan doprinos nauci
kao izraz priznanja za doprinos razvoju antimalarika i inhibitora botulinum neurotoksina i ebole

Ostale aktivnosti

Dopisni član Srpske akademije nauka i umetnosti od 2. 11. 2006. do 31. 10. 2012. - Odeljenje hemijskih i bioloških nauka.

Redovni član Srpske akademije nauka i umetnosti od 1. 11. 2012. - Odeljenje hemijskih i bioloških nauka.

Član sledećih naučnih društava:

Šef Katedre za organsku hemiju od 1. 10. 2015. do 30. 9. 2016.

Dobitnik stipendije Švajcarskog fonda za nauku 1985-1986, i stipendije Legerlotz fondacije 1986-1987.

Član naučnog odbora Istraživačkog instituta Galenika od 2003. do 2005.

Predsednik Saveta Hemijskog fakulteta 2004-2005

Direktor Inovacionog centra Hemijskog fakulteta od 2009.

Orcid.org/0000-0002-9975-2725

Učešće u naučnoistraživačkim projektima

Završeni projekti:

  • 2009-2012: Multi-targeted compounds – NO HHSN261200800001E   (rukovodilac projekta)
    vrsta projekta:   međunarodni
    projekat finansira:   SAIC-Frederick, Inc. - NCI at Frederick (Frederick, Sjedinjene Američke Države)
  • 2010: Novi inhibitori Botulinum neurotoksina – NATO CBP EAP.SFPP 983638   (rukovodilac projekta)
    vrsta projekta:   međunarodni
    projekat finansira:   NATO (Brussels, Belgija)
  • 2010: Jačanje Hemijskog fakulteta Univerziteta u Beogradu u cilju uspostavljanja Centra izvrsnosti za molekularnu biotehnologiju i istraživanje hrane u regionu Zapadnog Balkana – FCUB-ERA 256716
    vrsta projekta:   međunarodni
    projekat finansira:   Evropska unija (Brisel, Belgija)
  • 2011: Sinteza aminohinolina i njihovih derivata kao antimalarika i inhibitora botulinum neurotoksina A – 172008
    vrsta projekta:   domaći fundamentalni
    projekat finansira:   Ministarstvo za nauku i tehnološki razvoj Republike Srbije (Beograd)
  • 2009: Druga generacija malih molekula inhibitora Botulinum neurotoksina – 1U01AI082051-01   (rukovodilac projekta)
    vrsta projekta:   međunarodni
    projekat finansira:   National Institute of Health (Bethesda, Maryland, Sjedinjene Američke Države)
  • 2011: Kontrola infekcija apikompleksnim patogenima: od novih mesta delovanja leka do predikcije – 41019
    vrsta projekta:   domaći fundamentalni
    projekat finansira:   Ministarstvo za nauku i tehnološki razvoj Republike Srbije (Beograd)
  • 2016: Discovery and optimization of new antiparasitic compounds to treat and control malaria and leishmaniasis, to be used in both human and veterinary medicine – RS16MO04   (rukovodilac projekta)
    vrsta projekta:   međunarodni
  • 2015: Small Molecule Antiviral Inhibitors – 1323839   (rukovodilac projekta)
    vrsta projekta:   međunarodni

Izabrane reference

Knjige i revijalni radovi / Books and reviews:

  1. Preveo i uredio udžbenik Organska hemija (Organic chemistry), 2. i 4. američko izdanje (1994, 2003) autora K.P.C. Vollhardt-a i N. Shore-a, W.H. Freeman and Company, Datastatus Beograd. Prevod priručnika Uputstvo za rešavanje zadataka sa rešenjima. Organska hemija, struktura i funkcija. (The Study Guide) N. Schore, W.H. Freeman and Company

Reviews

  1. Reactions and Use of Diisobutylaluminium Hydride in Organic Synthesis, J. Serb. Chem. Soc., 1993, 58, 155-191, and the references cited therein.
  2. Antimalarial peroxides. Dejan M. Opsenica, Bogdan A. Šolaja. Journal of the Serbian Chemical Society 2009, 74, 1155–1193.
  3. Dejan M. Opsenica, Bogdan A. Šolaja, “Second-Generation Peroxides: The OZs and Artemisone” in “Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use”, Henry M. Staines, Sanjeev Krishna, (Eds.); Series: Milestones in Drug Therapy; Series Editors: Michael J. Parnham, Jacques Bruinvels. Springer, Basel, 2012. ISBN 978-3-0346-0479-6
  4. Artemisinins and synthetic peroxides as highly efficient antimalarials. Dejan M. Opsenica, Bogdan A. Šolaja. Macedonian Journal of Chemistry and Chemical Engineering, 2012, 31, 137–182.

Izabrani radovi / Selected papers:

Antimalarials

  1. Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: structure determination and their antimalarial activity, N. Todorović, M. Stefanović, B. Tinant, J-P. Declercq, M. Makler, B. Šolaja, Steroids, 1996, 61, 688-696.
  2. Cholic Acid Derivatives as 1,2,4,5-Tetraoxane Carriers: Structure, Antimalarial and Antiproliferative Activity. D. Opsenica, G. Pocsfalvi, Z. Juranić, B Tinant, J.-P. Declercq, D. E. Kyle, W. K. Milhous, B. A. Šolaja, J. Med. Chem., 2000,43, 3274-3282.
  3. Mixed Steroidal 1,2,4,5-Tetraoxanes: Antimalarial and Antimycobacterial Activity. B. A. Šolaja, N. Terzić, G. Pocsfalvi, L. Gerena, B. Tinant, D. Opsenica, W. K. Milhous, J. Med. Chem., 2002, 45, 3331-3336.
  4. Antimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanes. D. Opsenica, D. E. Kyle, W. K. Milhous, B. A. Šolaja, J. Serb. Chem. Soc., 2003, 68, 291–302.
  5. Antimalarial and Antiproliferative Evaluation of Bis-Steroidal Tetraoxanes. D. Opsenica, G. Angelovski, G. Pocsfalvi, Z. Juranić, Ž. Žižak, D. Kyle, W. K. Milhous, B. A. Šolaja, Bioorganic & Medicinal Chemistry, 2003, 11, 2761-2768.
  6. Structure-activity relationship study of steroidal 1,2,4,5-tetraoxane antimalarials using computational procedures. A. K. Bhattacharjee, K. A. Carvalho, D. Opsenica, B. A. Šolaja, J. Serb. Chem. Soc., 2005, 70, 329-345.
  7. Tetraoxane Antimalarials and Their Reaction with Fe(II). I. Opsenica, N. Terzić, D. Opsenica, G. Angelovski, M. Lehnig, P. Eilbracht, B. Tinant, Z. Juranić, K. S. Smith, Y. S. Yang, D. S. Diaz, P. L. Smith, W. K. Milhous, D. Doković, B. A. Šolaja, J. Med. Chem., 2006, 49, 3790-3799.
  8. Deoxycholic Acid-Derived Tetraoxane Antimalarials and Antiproliferatives. N. Terzić, D. Opsenica, D. Milić, B. T., K. S. Smith, W. K. Milhous, B. A. Šolaja, J. Med. Chem., 2007, 50, 5118-5127.
  9. On peroxide antimalarials. I. Opsenica, D. Opsenica, M. Jadranin, K. S. Smith, W. K. Milhous, M. Stratakis and B. Šolaja. J. Serb. Chem. Soc., 2007, 71, 1181–1190.
  10. Chemical Stability of the Peroxide Bond Enables Diversified Synthesis of Potent Tetraoxane Antimalarials. Opsenica, I.; Opsenica, D.; Smith, K.S.; Milhous, W.K.; Šolaja, B.A. J. Med. Chem., 2008, 51, 2261-2266.
  11. Mixed tetraoxanes containing the acetone subunit as antimalarials. Dejan M. Opsenica, Nataša Terzić, Philip L. Smith, Youngsun Yang, Lalaine Anova, Kirsten S. Smith, Bogdan A. Šolaja. Bioorganic & Medicinal Chemistry, 2008, 16, 7039–7045.
  12. New Chimeric Antimalarials with 4-Aminoquinoline Moiety Linked to a Tetraoxane Skeleton. Opsenica, Igor; Opsenica, Dejan; Lanteri, Charlotte Anne; Anova, Lalaine; Milhous, Wilbur K.; Smith, Kirsten S.; Šolaja, Bogdan A. J. Med. Chem., 2008, 51, 6216-6219.
  13. Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells. Žižak, Ž.; Juranić, Z.; Opsenica, D.; Šolaja, B. Investigational New Drugs, 2009, 27, 432-439.
  14. Correlation between structure, retention and activity of cholic acid derived cis–trans isomeric bis-steroidal tetraoxanes. Šegan, S., Andrić, F., Radoičić, A., Opsenica, D., Šolaja, B., Zlatović, M. and Milojković-Opsenica, D. J. Sep. Sci. 2011, 34, 1–9.
  15. 4-Amino-7-chloroquinolines: Probing ligand efficiency provides botulinum neurotoxin serotype a light chain inhibitors with significant antiprotozoal activity. Opsenica, I.M., Tot, M., Gomba, L., Nuss, J.E. , Sciotti, R.J., Bavari, S., Burnett, J.C., Šolaja, B.A. Journal of Medicinal Chemistry, 2013, 56 (14), 5860-5871.
  16. Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria. Videnović M, Opsenica DM, Burnett JC, Gomba L, Nuss JE, Selaković Z, Konstantinović J, Krstić M, Segan S, Zlatović M, Sciotti RJ, Bavari S, Solaja BA. J Med Chem. 2014, 57, 4134-4153.
  17. Correlation study of retention data and antimalarial activity of 1,2,4,5-mixed tetraoxanes with their molecular structure descriptors and LSER parameters. Sandra Šegan, Nataša Terzić-Jovanović, Dušanka Milojković-Opsenica, Jelena Trifković, Bogdan Šolaja, Dejan Opsenica. Journal of Pharmaceutical and Biomedical Analysis 2014, 97, 178-183.
  18. I. M. Opsenica, T. Ž. Verbić, M. Tot, R. J. Sciotti, B. S. Pybus, O. Djurković-Djaković, K. Slavić, B. A. Šolaja, Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice, Bioorg. Med. Chem. 2015, 23, 2176-2186.
  19. Re-investigating old pharmacophores: Are 4-aminoquinolines and tetraoxanes potential two-stage antimalarials? Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković,  Jelena Srbljanović,Tijana Štajner,Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Rick Sciotti,Stevan Pecic,Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja. J. Med. Chem. Just Accepted Manuscript , DOI: 10.1021/acs.jmedchem.5b01374.

Botulinum Neurotoxin Inhibitors

  1. A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease. J. C. Burnett, D. Opsenica, K. Sriraghavan, R. G. Panchal, G. Ruthel, A. R. Hermone, T. L. Nguyen, T. A. Kenny, D. J. Lane, C. F. McGrath, J. J. Schmidt, J. L. Vennerstrom, R. Gussio, B. A. Šolaja, S. Bavari. J. Med. Chem., 2007, 50, 2127-2136.
  2. Novel 4-Aminoquinolines Active against Chloroquine-Resistant and Sensitive P. falciparum Strains that also Inhibit Botulinum Serotype A. Bogdan A. Šolaja, Dejan Opsenica, Kirsten S. Smith, Wilbur K. Milhous, Nataša Terzić, Igor Opsenica, James C. Burnett, Jon Nuss, Rick Gussio, Sina Bavari. J. Med. Chem., 2008, 51, 4388–4391.
  3. Three-Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three-Zone Pharmacophore. Hermone, A.R.; Burnett, J. C.; Nuss, J. E.; Tressler, L. E.; Nguyen, T. L.;Šolaja, B.A., Vennerstrom, J. V.; Schmidt, J. J.; Wipf, P.; Bavari, S.; Gussio, R. ChemMedChem, 2008, 3, 1905-1912.
  4. A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus. Igor Opsenica, James C. Burnett, Rick Gussio, Dejan Opsenica, Nina Todorović, Charlotte A. Lanteri, Richard J. Sciotti, Montip Gettayacamin, Nicoletta Basilico, Donatella Taramelli, Jonathan E. Nuss, Laura Wanner, Rekha G. Panchal, Bogdan A. Šolaja, Sina Bavari. Journal of Medicinal Chemistry  2011,  54,  1157–1169.
  5. The synthesis of 2,5-Bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease. Igor Opsenica, Vuk Filipovic, Jon E. Nuss, Laura M. Gomba, Dejan Opsenica, James C. Burnett, Rick Gussio, Sina Bavari, Bogdan A. Solaja. European Journal of Medicinal Chemistry, 2012, 53, 374-379.
  6. 4-Amino-7-chloroquinolines: Probing ligand efficiency provides botulinum neurotoxin serotype a light chain inhibitors with significant antiprotozoal activity. Opsenica, I.M., Tot, M., Gomba, L., Nuss, J.E. , Sciotti, R.J., Bavari, S., Burnett, J.C., Šolaja, B.A. Journal of Medicinal Chemistry, 2013, 56 (14), 5860-5871.
  7. New 9-aminoacridine derivatives as inhibitors of botulinum neurotoxins and P. falciparum malaria. Mikloš Tot, Dejan M. Opsenica, Milena Mitrić, James C. Burnett, Laura Gomba, Sina Bavari, Bogdan A. Šolaja. J. Serb. Chem. Soc. 2013, 78 (12), 1847–1864.
  8. Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria. Videnović M, Opsenica DM, Burnett JC, Gomba L, Nuss JE, Selaković Z, Konstantinović J, Krstić M, Segan S, Zlatović M, Sciotti RJ, Bavari S, Solaja BA. J Med Chem. 2014, 57, 4134-4153.

Ebola inhibitors

  1. A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus. Igor Opsenica, James C. Burnett, Rick Gussio, Dejan Opsenica, Nina Todorović, Charlotte A. Lanteri, Richard J. Sciotti, Montip Gettayacamin, Nicoletta Basilico, Donatella Taramelli, Jonathan E. Nuss, Laura Wanner, Rekha G. Panchal, Bogdan A. Šolaja, Sina Bavari. J. Med. Chem. 2011, 54, 1157–1169.
  2. A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor. Života Selaković, Dejan Opsenica, Brett Eaton, Cary Retterer, Sina Bavari, James C. Burnett, Bogdan A. Šolaja, Rekha G. Panchal. Viruses 2012, 4, 1279-1288.
  3. Anti-Ebola Activity of Diazachrysene Small Molecules. Života Selaković, Veronica Soloveva, Dima N. Gharaibeh, Jay Wells, Sandra Šegan, Rekha G. Panchal, and Bogdan A. Šolaja. ACS Infect. Dis. 2015, 1, 264−271.

Miscellaneous

  1. Steroidal Analogue of Deoxyvernolepin. Synthesis of gamma-Lactone Key Intermediate, B. Šolaja, M. Stefanović, Croat. Chim. Acta, 1986, 59, 1.
  2. The Synthesis of Trimethylcyclopentanecarboxylic Acids, B. Šolaja, J. Huguet, M. Karpf, A.S. Dreiding, Helv. Chim. Acta, 1986, 69, 1163.
  3. The Synthesis of (+,-)-Isoptychanolide by Application of the alpha-Alkynone Cyclisation, B. Šolaja, J. Huguet, M. Karpf, A.S. Dreiding, Tetrahedron, 1987, 43, 4875.
  4. Transformations of Some Steroidal Lactones and Study of Nucleophilic Substitution at 6alpha,7beta-Epoxides, B. Šolaja, Lj. Došen-Mićović, J. Serb. Chem. Soc., 1989, 54, 657.
  5. Oxidation of steroidal 5-en-3beta-ols with Jones reagent in ether, B. Šolaja, D. Milić, Lj. Došen-Mićović, Steroids, 1994, 59, 330-334.
  6. A Novel m-CPBA Oxidation: p-Quinols and Epoxyquinols from Phenols, B. Šolaja, D. Milić, M. Gašić, Tetrahedron Lett., 1996 (21) 3765-3768.
  7. The Synthesis and Biological Evaluation of A-Ring Substituted Steroidal p-Quinones, D. Milić, M. Gašić, W. Muster, J. Csanadi, B. Šolaja, Tetrahedron, 1997, 53, 14073-14084.
  8. The synthesis and in vitro activity of some DELTA7,9(11)-lanostadienes, B. Šolaja, M. Đermanović, D-M. Lim, Y-K. Paik, B. Tinant, J-P. Declerq, Steroids, 1997, 62, 709-718.
  9. Synthesis and Antiproliferative Activity of Epoxy and Bromo Compounds Derived from Estrone. D. R. Milić, T. Kop, Z. Juranić, M. J. Gašić, B. A. Šolaja, Bioorganic and Medicinal Chemistry Letters, 2001, 11, 2197-2200.
  10. Synthesis and antiproliferative activity of A-ring aromatised and conduritol-like steroidal compounds. D. Milić, T. Kop, Z. Juranić, M. J. Gašić, B. Tinant, G. Pocsfalvi, B. A. Šolaja, Steroids, 2005, 70, 922-932.
  11. Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system. Dragana Milica, Tatjana Kop, Janos Csanadi, Zorica Juranic, Zeljko Zizak, Miroslav J. Gasic, Bogdan Solaja. Steroids, 2009, 74, 890–895.
  12. Double Palladium-Catalyzed Synthesis of Azepines. Nina Božinović, Igor Opsenica, Bogdan A. Šolaja, Synlett 2013, 24 (1), 49.
  13. Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives. Šegan, S, Trifković, J. Verbić, T., Opsenica, D., Zlatović, M., Burnett, J., Šolaja, B., Milojković-Opsenica, D. Journal of Pharmaceutical and Biomedical Analysis  2013, 72, 231-239.

Patents

  1. YU-49004/03. Lanosta-7,9-dien-3alpha,32-diol i postupak za njegovu sintezu.
  2. US 6,906,098 B2. Mixed Steroidal 1,2,4,5-Tetraoxane Compounds and Methods of Making and Using Thereof.
  3. YU-49498. Katalitički postupak za dobivanje hidrazida nikotinskih kiselina.
ACS Infect. Dis/strong/em