Course code:
553S1		 Course name:
Human Health and Environment Risk Assessment

Academic year:

2019/2020.

Attendance requirements:

There are no requirements.

ECTS:

9

Study level:

graduate academic studies

Study program:

Environmental Chemistry: 1. year, winter semester, compulsory course

Teacher:

Dubravka J. Relić, Ph.D.
associate professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistant:

Slađana D. Savić
teaching assistant, Faculty of Chemistry, Studentski trg 12-16, Beograd

Hours of instruction:

Weekly: four hours of lectures + two hours of exercises + three hours of labwork (4+2+3)

  Course activities and grading method

Lectures:

10 points (4 hours a week)

Syllabus:

1. Basic definitions and data sources. 2. Basic concepts from toxicology. 3. Dose-response, reference toxicological values. 4. Risk ratio, odds ratio, cohort, case control, matrix of risk.. 5. USEPA (United States Environmental Protection Agency) - Risk assessment. 6. Human health risk assessment - Exposure assessment; quantification of exposure; toxicity assessment; risk characterization 7. Human Risk Assessment II - EEA model (DNEL, DMEL). 8. Chemical agents. 9. Bilogenic agents and physical agents. 10. Tier approach, concept model, CLEA 11. Ecological risk assessment I - EEA model. 12. Ecological risk assessment II - USEPA model. 13. EEA - REACH (Registration, Evaluation, Authorization and Restriction of Chemicals). 14. Legislation and guidelines in the environment.

Exercises:

10 points (2 hours a week)

Syllabus:

Topic 1: Calculating the risk based on given input data. Topic 2: Calculating the risk based on given input data, adjustable formulas.

Labwork:

10 points (3 hours a week)

Syllabus:

1. Determination of total content of elements in soil samples around buildings or houses - sample digestion and determination of element concentrations using ICP OES and / or XRF analysis of soil sample .
2. Determination of total content of elements in drinking water samples - by ICP OES and / or ICP MS.
3. Determination of the total content of elements in dust samples - sample digestion and determination of element concentrations by ICP OES and / or XRF analysis of dust samples.
4. Determination of bioavaiable fraction of elements from soil and dust samples, simulation of the influence of GI tract and stomach enzymes - recording of elements in extracts by ICP OES and / or ICP MS.
5. Creating a risk matrix based on working during laboratory exercises.
6. Calculation of non-carcinogenic and carcinogenic risk based on the results obtained

Semester papers:

10 points

Oral exam:

60 points