New Synthetic Methods   (272H2)

Academic year:

2024/2025.

Attendance requirements:

There are no requirements.

ECTS:

10

Study level:

Study programs:

Teacher:

Radomir N. Saičić, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

—

Hours of instruction:

Weekly: five hours of lectures + three hours of study research work

Goals:

Students should get acquainted with novel developments in organic synthesis, which include: 1) New reactions; 2) New reagents and catalysts; 3) Modified conditions for conducting organic reactions; 4) Catalytic asymmetric synthesis; and 5) Domino reactions.

Outcome:

Capacity to independently select and apply optimal synthetic procedures in order to solve synthetic problems in the domain of research work and/or industrial application.

Teaching methods:

Lectures, seminal works.

Extracurricular activities:

—

Coursebooks:

• R. N. Saicic: Synthesis of Complex Organic Molecules, notes for internal use, 2021.
• I. Ojima: Catalytic Asymmetric Synthesis, Wiley VCH, N. Y., 2000. ISBN 0-471-29805-0
• L. S. Hegedus: Transition Metals in the Synthesis of Complex Organic Molecules, University Science Books, Sausalito, California, 1999. ISBN 1-891389-04-1
• J. Tsuji: Transition Metal Reagents and Catalysts, John Wiley & Sons, N. Y., 2000. ISBN: 0-471-56027-8

Additional material:

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Lectures:

15 points (5 hours a week)

Syllabus:

• Fundamentals of the reactivity of organotransition metal complexes;
• Enantioselective hydrogenations;
• Cross couplings;
• The Heck reaction;
• Alkene metathesis;
• Reactions catalyzed by gold complexes;
• Reactions catalyzed by cobalt complexes;
• Enantioselective oxidations;
• Organocatalysis;
• Domino-reactions;
• Solid supported synthesis;
• Photoredox reactions.

Semester papers:

15 points

Oral exam:

70 points

Study research work:

0 points (3 hours a week)