Course code:
1191B		 Course name:
Bioinorganic Chemistry

Academic year:

2012/2013.

Attendance requirements:

1102B

ECTS:

6

Study level:

basic academic studies

Study programs:

Biochemistry: 4. year, summer semester, elective (1IP6B) course

Biochemistry: 4. year, summer semester, elective (1IP5B) course

Teacher:

Gordana N. Vučković, Ph.D.

Assistant:

Aleksandar R. Savić, Ph.D.
assistant professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Hours of instruction:

Weekly: four hours of lectures + two hours of labwork (4+0+2)

Goals:

Introduce students to the basic bioinorganic chemistry, methods applied, corresponding literature, especially new scientific papers.

Outcome:

After course the student would be able to understand the possible practical application of this discipline in medicine, pharmacy, diet, environmental protection.

Teaching methods:

Interactive,classical and consultative teaching, semester papers and experimental work.

Extracurricular activities:

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Coursebooks:

Main coursebooks:

  • K. B. Jacimirskij: Introduction to bioinorganic chemistry, translated from russian, Privredni pregled, Belgrade, 1980.
  • H. B. Bertini, S. J. Lippard: Principles in Bioinorganic Chemistry, University Science Book, 1994.

Supplementary coursebooks:

  • J. A. Cowan: Inorganic Biochemistry, An introduction, 2nd ed, Wiley-VCH, New York, 1997.
  • M. N. Hughes: The Inorganic Chemistry of Biological Processes, J. Wiley and Sons, London, 1974.
  • Internet, scientific papers, popular literature.

Additional material:

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  Course activities and grading method

Lectures:

10 points (4 hours a week)

Syllabus:

1. The subject and development of bioinorganic chemistry.

2. Methods for the investigations of biocomplexes (for each of them advantages and limitations will be discuss).

3. Bioligands (division and interactions with biometals).

4-6. Distribution of bioelements in human organism and their importance. Biometals.

7-9. Metalloenzymes as catalysts for hydrolytic and redox reactions.

10-11. Model systems and probes. Blood alternatives.

12. Toxyc elements, inhibition and eliminations from organism.

13-14. Application of metals and their compounds in medicine, pharmacy, diet and environmental protection.

15. Colloquia.

Labwork:

10 points (2 hours a week)

Syllabus:

1-5. Preparation of the coordination compounds with potentially bioactive ligands. Exploration of the literature, synthesis, analysis, spectral study, magnetic measurements, etc.

6-10. Microbiological test of the complexes, ligands and solvent.

11-14. Discussion about prepared complexes.

15. Test.

Semester papers:

20 points

Colloquia:

10 points

Written exam:

50 points