Course code:
414B2		 Course name:
Biotechnological and Industrial Biochemistry

Academic year:

2024/2025.

Attendance requirements:

064B2 + 412B2

ECTS:

7

Study level:

basic academic studies

Study program:

Biochemistry: 4. year, summer semester, elective (E16B2) course

Teacher:

Vladimir P. Beškoski, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistant:

Kristina B. Kasalica
junior research assistant, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, Beograd

Hours of instruction:

Weekly: two hours of lectures + four hours of labwork (2+0+4)

Goals:

The application of the knowledge and skills acquired in biochemical and biotechnical courses with the aim of obtaining products and performing the procedures which are necessary in everyday life.

Outcome:

In this course, students will find out that fundamental knowledge is a prerequisite for its application, which is inevitable and the moving force of the progress.

Teaching methods:

Interactive teaching, laboratory classes and term papers.

Extracurricular activities:

Preparing for laboratory classes and organizing one’s laboratory notebook, searching for and collecting literature, writing term papers and essays, studying.

Coursebooks:
  1. D. A. Đukić, L. G. Mandić: Tehnologija mikrobioloških proizvoda, Prosveta, Beograd, 2012.
  2. S. Šiler-Marinković: Mikrobna biomasa, TMF, Beograd, 2006.
  3. Lj. Mojović: Biohemijsko inženjerstvo, TMF, Beograd, 2006.
  4. S. Dodić, S. Popov: Bioreaktori, Tehnološki fakultet, Novi Sad, 2009.
  5. J .Vučetić, M. M. Vrvić: Mikrobiološke sinteze vitamina, Nova prosveta, Beograd, 1992.
  6. J. I. Vučetić, M. M. Dabović: Mikrobiološke transformacije i biosinteze nekih organskih jedinjenja, Centar za hemiju IHTM, Beograd, 1997.
  7. M. Moo-Young (editor): Comprehensive Biotechnology (Second Edition), Elsevier, Amsterdam, 2011.
  8. R. H. Baltz, J. E. Davies, A. L. Demain (editors): Manual of Industrial Microbiology and Biotechnology, 3rd Edition, ASM Press, Washington DC, 2010.

Additional material:

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  Course activities and grading method

Lectures:

5 points (2 hours a week)

Syllabus:

  1. Microbiological syntheses (MBS) – biotechnological production of amino acids and some nucleotide monophosphates.
  2. MBS of polysaccharides, lipids, lipopolysaccharides, glycolipids and tetrapyrroles.
  3. Milk: foodstuff, biotechnological substrate and raw material. Tobacco fermentation.
  4. Alcoholic fermentation and organic acids.
  5. MBS - biotechnological production of enzymes.
  6. MBS - biotechnological production of vitamins.
  7. MBS - biotechnological production of antibiotics.
  8. Microbiological fertilizers.
  9. The recapitulation of the operationalization of biotechnological processes.
  10. Microbial biogeotechnology (BGT): the current state and prospects.
  11. Other applications of BGT and bioelectrochemical processes.
  12. Bioremediation.
  13. Biomass (BM) production: importance, potentials and applications.
  14. BM and energy.
  15. Vaccines - classical, recombinant, edible. Bacteriophages and other microbial preparations for the normalization of animal and human gastrointestinal microflora.

Labwork:

15 points (4 hours a week)

Syllabus:

Students work in teams in order to carry out mini projects of their own choice, such as: the production of beer or wine in a laboratory, bioleaching of copper from off-balance raw materials, bioremediation of the soil contaminated by petroleum and its derivatives, the production of antibiotics and enzymes by streptomycetes, microbial desulfurization of fossil fuels, prebiotics and probiotics, determining the number of bacteriophages, molecular characterization of the strains isolated from the polluted environment.

Semester papers:

30 points

Oral exam:

50 points