Group Members

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Research Area

Chemistry of Heterocyclic Compounds

Heterocyclic compounds are one of the most commonly found structures in organic chemistry, and chemistry in general. Many natural products and current drugs consist of at least one heterocyclic system.

The scope of our studies encompasses the synthesis, transformation and applications of heterocycles. Current studies are focused on aromatic and partially unsaturated heterocyclic compounds.

Organometallic Chemistry

A carbon-carbon and carbon-heteroatom bond formation via transition-metal catalysis is of great importance in organic synthesis. On the other hand, breaking up the C-C and C-X bond is also important aspect in organic chemistry.

Our research group works on the use of homogeneous and heterogeneous transition metal-catalyzed C-C and C-heteroatom cross-coupling.

Green Chemistry

Our group is also interested in the application of the principles of green chemistry in organic synthesis. The research group has great experience in developing quick, eco-friendly and energetically efficient routes for synthesis of biologically relevant compounds. The part of our research is focused on the solid-supported catalysis and microwave-assisted organic synthesis (MAOS).

Medicinal Chemistry

Our group has a longtime experience in designing pharmacophore-guided libraries of compounds active against eukaryotic pathogens, such as fungi and parasites, as well as viruses, bacteria and cancer cells, and understanding their mechanism of action in biological systems. Over the past few years we have worked in interdisciplinary research which brings together researchers from organic synthesis, medicinal chemistry, and microbiology.

Publications

Books:

  • I. Opsenica: Hemija heterocikličnih jedinjenja I, Hemijski fakultet, Beograd, 2016.
  • I. Opsenica: Hemija heterocikličnih jedinjenja II, Hemijski fakultet, Beograd, 2021.

Reviews:

  • B. Kokić, B. Vulović, M. Jović, A. Andrijević, V. Ajdačić, I. M. Opsenica, Strategies for carbon electrophile addition to carbonyls and imines by cobalt catalysis, Eur. J. Org. Chem., 2023, 26, e202300997.
  • Ž. Selaković, A. M. Nikolić, V. Ajdačić, I. M. Opsenica, Application of transition metal-catalyzed decarbonylation of aldehydes in the total synthesis of natural products, Eur. J. Org. Chem., 2022, e202101265.

Selected papers:

  1. A. M. Nikolić, J. Stanić, M. Zlatar, M. Gruden, B. Anđelković, Ž. Selaković, V. Ajdačić, I. M. Opsenica, Controlling Pd-catalyzed N‑arylation and Dimroth rearrangement in the synthesis of N,1-diaryl‑1H‑tetrazol-5-amines, J. Org. Chem., 2021, 86, 4794-4803.
  2. A. M. Nikolić, F. Živković, Ž. Selaković, P. Wipf, I. M. Opsenica, One-pot two-step synthesis of isochromene-fused CF3-substituted pyrazoles, Eur. J. Org. Chem., 2020, 5616-5619.
  3. S. Jeremic, L. Djokic, V, Ajdačić, N. Božinović, V. Pavlović, D. D. Manojlović, R. Babu, R. Senthamaraikannan, O. Rojas, I. Opsenica, J. Nikodinovic-Runic, Production of bacterial nanocellulose (BNC) and its application as a solid support in transition metal catalysed cross-coupling reactions, Int. J. Biol. Macromol., 2019, 129, 351-360.
  4. M. Videnović, M. Mojsin, M. Stevanović, I. Opsenica, T. Srdić-Rajić, B. Šolaja, Benzothiazole carbamates and amides as antiproliferative species, Eur. J. Med. Chem., 2018, 157, 1096-1114.
  5. V. Ajdačić, A. Nikolić, S. Simić, D. Manojlović, Z. Stojanović, J. Nikodinovic-Runic, I. M. Opsenica, Decarbonylation of aromatic aldehydes and dehalogenation of aryl halides using maghemite-supported palladium catalyst, Synthesis, 2018, 50, 119-126.

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