Course code:
411A1		 Course name:
Chemistry of Natural Products

Academic year:

2019/2020.

Attendance requirements:

200A1 + 200E1

ECTS:

7

Study level:

basic academic studies, integrated basic and graduate academic studies

Study programs:

Chemistry: 3. year, winter semester, compulsory course

Environmental Chemistry: 3. year, winter semester, compulsory course

Chemical Education: 3. year, winter semester, compulsory course

Teacher:

Radivoje M. Prodanoviæ, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

Nikolina V. Popoviæ Kokar, Ph.D.
research associate, Faculty of Chemistry, Studentski trg 12-16, Beograd

Milica M. Crnoglavac Popoviæ
research assistant, Faculty of Chemistry, Studentski trg 12-16, Beograd

Hours of instruction:

Weekly: three hours of lectures + three hours of labwork (3+0+3)

Goals:

The goal of this course is to help students master the basic principles of isolation, purification, identification, characterization and determination of the structure of the most important classes of natural products. The course also examines the roles these molecules have in the organisms which produce them with the focus on secondary metabolites, their biosynthesis, physiological activity and application.

Outcome:

Students have mastered the basic principles of isolation, purification, identification, characterization and determination of the structure of the most important classes of natural products.

Teaching methods:

Lectures, exercises, term papers.

Extracurricular activities:

—

Coursebooks:

Main coursebooks:

  • Slobodan Petrović, Dušan Mijin, Nadežda Stojanović: Hemija prirodnih organskih jedinjenja, Tehnološko-metalurški fakultet, Beograd, 2005.
  • Lehninger: Principles of Biochemistry, W. H. Freeman and Co, 2005.

Supplementary coursebooks:

  • K. B. G. Torssell: Natural Products Chemistry, Apotekarsocieteten, Stockholm, 1995.
  • R. M. Jankov, N. Polović, T. Ćirković Veličković: Praktikum - Hemija prirodnih proizvoda, Hemijski fakultet, Beograd, 2006. ISBN: 86-7220-028-4

Additional material:

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  Course activities and grading method

Lectures:

0 points (3 hours a week)

Syllabus:

  • Proteins: amino acids and peptides, properties, isolation, analytics, biosynthesis. Protein structure, isolation and characterization. Fundamentals of physiological activity of peptides and the function of some classes of proteins.
  • Saccharides: the basics of monosaccharides. Glycosides. Oligosaccharides and polysaccharides. Properties, isolation, analytics, characterization, biosynthesis. Physiological role of some saccharides and technical application.
  • Lipids: neutral fats, phospholipids, glycolipids, waxes, prostaglandins, steroids, terpenoids. The principles of isolation, characterization, structure determination and biosynthesis. The role of the main representatives of various classes of lipids. The structure of the cell membrane. The structure of microbial cell walls.
  • Alkaloids: classification, basic concepts regarding structure, isolation, characterization, biosynthesis and physiological action in higher organisms. Fundamentals of antibiotics, vitamins, plant pigments and natural aromatic compounds (depsides, lignins, tannins, quinones).
  • Nucleic acids: basic information, structure, isolation, purification and analytics of NA. Nucleosides, nucleotides and the classes of nucleic acids, their structure, biosynthesis, physiological role and application.

Labwork:

0 points (3 hours a week)

Syllabus:

Exercises are done in five areas: 1. proteins, 2. carbohydrates, 3. lipids and steroids, 4. terpenoids, alkaloids, vitamins and antibiotics, 5. nucleic acids. Students’ experimental work in every of the above-mentioned areas includes practicing experimental techniques for isolation, purification and characterization of one substance from a group of several preparations which students can carry out.

Semester papers:

10 points

Colloquia:

20 points

Written exam:

20 points

Oral exam:

50 points