[dr Sanja R. Grguric Sipka]

Faculty of Chemistry, Studentski trg 12-16, Beograd
Department of General and Inorganic Chemistry

Phone:   011-3336736 (in laboratory 525), 011-3336742 (in office 535)

Phone (local):   736 (in laboratory 525), 742 (in office 535)

Office:   534

Laboratory:   525

E-mail:   sanjag@chem.bg.ac.rs

Personal data

Born on August 28. 1971 in Belgrade, Serbia. Married. Two children.

Education and qualifications

1990-1994: Undergraduate studies - Chemistry / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1995-1998: Master of science studies - Chemistry / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1999-2003: Doctoral academic (PhD) studies - Chemistry / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

History of employment

1995-1996: Junior associate / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1997: Assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1997-2001: Graduate assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1999-2003: Assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2004-2010: Assistant professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2010: Associate professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2015: Full professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

Scientific interest

Coordination chemistry, bioinorganic chemistry

Awards and merits

2005: Austria science fund, Lisa Meitner fellowship

Other activities

Member of Serbian Chemical Society from 1994.

Head of the Deparment of General and Inorganic Chemistry from March 8, 2011 till January 20, 2016.

Head of the Deparment of General and Inorganic Chemistry from October 1, 2023.

Educational activities

Participation in research projects

Active projects:

Finished projects:

  • 2011: Rational Design and Synthesis of Bioactive and Coordination Compounds and Functional Materials Relevant for (bio)Nanotechnology – 172035
    project type:   National Fundamental Research Projects
    project is funded by: Ministry of Science and Technological Development (Belgrade, Serbia)
  • 2012-2016: Functional metal complexes that bind to biomolecules – CMST COST Action CM1105
    project type:   International
    project is funded by: European Union (Brusseles, Belgium)

Author identification numbers

Representative references

Knjige i revijalni radovi / Books and reviews:

  1. Sabo, T. J.; Grgurić-Šipka, S.R.; Trifunović, S.R. Transition metal complexes with edda-type ligands. Synth. React. Inorg. Met.-org. Chem., (2002) 32 1661-1717.
  2. Gligorijević,N.; Arandjelović,S.; Jovanović, K.; Grgurić-Šipka, S.; Radulović, S.: The development of Ru(II)-p-Cymene derivativesd as Anti-Cancer Agents, in Ruthenium Chemistry 2018, 215-258. CRC Press, Taylor and Francis. 
  3. Mihajlović-Lalić, Lj.E.; Poljarević, J.; Grgurić-Šipka, S.: Metal complexes with α-picolinic acid frameworks and their antitumor activity, Inorg. Chim. Acta, 527 (2021) 120582. 
  4. M.Gruden-Pavlović, S.Grgurić-Šipka, S.Grubišić, S.R.Niketić, Praktikum iz opšte hemije, Hemijski fakultet, Beograd, 2008.
  5. S. Grgurić-Šipka, Hemija bioelemenata, Hemijski fakultet, Beograd, 2014.

Izabrani radovi / Selected papers:

  • Nikolić, S.;  Arakelyan,J.;  Kushnarev, V.; Alfadul, S.M.; Stanković, D.; Y. I. Kraynik, Y. I.; Grgurić-Šipka, S.;  Babak, M.V.; Coordination of Ru(II)-arene fragments to dipyridophenazine ligands leads to the modulation of their in vitro and in vivo anticancer activity, Inorg. Chem., 62 (2023) 8188-8199. 
  • Mrkalić, E. M.;Šmit B.; Matić S.Lj. Jelić, R.J.; Čendić Serafinović, M.; Gligorijević, N.; Čavić, M.; Aranđelović, S.; Grgurić-Šipka, S.; Soldatović, T.V.: Exploring heterometalic bridged Pt(II)-Zn(II) complexes as potential antitumor agents, J. Inorg. Biochem.., 240 (2023) 112100.  
  • Petrović, T.; Gligorijević, N.; Belaj, F.: Aranđelović, S.; Mihajlović-Lalić, Ll. E. Grgurić-Šipka, S.; Poljarević, J.: Drug combination study of novel oxorhenium(V) complexes, J. Inorg. Biochem., 231 (2022) 1118,
  • Margetić, A.; Nikolić, S.; Grgurić-Šipka, S; Vujčić, M.T.: Interaction of organoruthenium(II)-polypyridyl complexes with DNA and BSA, Biometals, 35 (2022) 813-829
  • Stanic-Vucinic, D.; Nikolić, S.:  Vlajic, K.;  Radomirovic, M.; Mihailovic Vesic, J.; Cirković Velickovic, T.; Grgurić-Šipka, S.: The interactions of the ruthenium(II)-cymene complexes with lysozyme and cytochrome c, J. Biol. Inorg. Chem, 25 (2020) 253-265
  • Pavlović, M.; Tadić, A.; Gligorijević, N.;Poljarević, J.; Petrović, T.; Dojčinović, B.; Savić, A.; Radulović, S.; Grgurić-Šipka, S;Aranđelović, S:Synthesis, Chemical characterization, PARP Inhibition, DNA Binding and Cellular Uptake of Novel Ruthenium(II)-Arene Complexes Bearing Benzamide Derivatives in Human Breast Cancer Cells, J. Inorg. Biochem. 210 (2020) 111155
  • Obradović, D.; Nikolić, S.; Milenković, I.; Milenković, M.; Jovanović, P.; Savić, V.;  Roller, A. Đorđić Crnogorac, M.; Stanojković, T.; Grgurić-Šipka, S.: Synthesis, characterization, antimicrobial and cytotoxic activity of novel half-sandwich Ru(II) arene complexes with benzoylthiourea derivatives, J. Inorg. Biochem. 210 (2020) 111164
  • Korać Jačić, J.; Nikolić, Lj.; Stanković, D.M.;  Opačić, M.; Dimitrijević, M.; Savić, D.;   Grgurić-Šipka, S.; Spasojević, I.;  Bogdanović-Pristov,  J.: Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors, Free Radical Biology and Medicine, 148 (2020) 123-127. 
  • Nikolić, S.;  Mihajlović-Lalić, Lj.E.; Vidosavljević, M.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.: Mono- and binuclear Ru(II) arene complexes with (fluoro substituated) picolinic acid: synthesis, characterization and cytotoxicity, J. Organomet. Chem., 902 (2019) 120966. 
  • Pavlović, M.; Nikolić, S.;  Gligorijević, N.; Dojčinović, B.; Aranđelović, S.; Grgurić-Šipka, S.; Radulović, S.: New organoruthenium compounds with pyrido[2',3':5,6]pyrazino[2,3-f][1,10]phenanthroline: synthesis, characterization, cytotoxicity and investigation of mechanism of action, J. Biol. Inorg. Chem., 24 (2019)  297-310. 
  • Pantić, D.N.; Mihajlović-Lalić, Lj:E; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.: Synthesis, characterization and cytotoxic activity of organoruthenium(II)-halido complexes with 4-chloro-1H-benzimidazole-2-carboxylic acid, J. Coord. Chem., 72 (2019) 908-919.
  • Nikolić, S.; Grgurić-Šipka, S.; Djordjević, I.S.; Dahmani, R.; Dekanski, D.; Vidičević, S.; Tošić, J.; Mitić, D.; Grubišić, S.: Half-Sandwich (Arene) Ruthenium(II) complexes: Synthesis, Spectroscopic Studies, Biological Properties and Molecular Modeling, J. Coord. Chem., 72 (2019) 148-163.
  • Korać, J.; Stanković, D.; Stanić, M.; Bajuk-Bogdanović, D.; Žižić, M.; Bogdanović Pristov J.; Grgurić-Šipka, S.; Popović-Bijelić, A.; Spasojević, I.: Coordinate and redox interactions of adrenaline with ferric and ferrous iron at pH 7.4, Sci. Rep., 8 (2018) 3530
  • Poljarević, J.; Tamas Gal, G.; May, N.V.; Spengler, G.; Domotor, O.; Savić, A.R.; Grgurić-Šipka, S.; Enyedy, E.A.: Comparative solution equilibrium and structural studies of half-sandwich ruthenium(II)(n6-toluene) complexes of picolinate derivatives, J. Inorg. Biochem., 181 (2018) 74-85. 
  • Tadić, A.; Poljarević, J.; Krstić, M.; Kajzerberger, M.; Aranđelović, S.; Radulović,S.; Kakoulidou, C.; Papadopoulos, A.N., Psomas, G.; Grgurić-Šipka, S.: Ruthenium arene complexes with NSAIDs: Synthesis, characterization and bioactivity, New. J. Chem., 42 (2018) 3001-3019.
  • Nikolić, S.; Ćirić, I.; Roller, A.; Lukes, V.; Arion, V.B.; Grgurić-Šipka, S: Conversion of hydrazides into N,N'-diacylhydrazines in the presence of ruthenium(II)-arene complexes, New J. Chem., 41, 2017, 6857-6865.
  • Misirlić-Denčić, S.; Poljarević, J.; Isaković, A.M.; Marković, I.; Sabo, T.J.; Grgurić-Šipka, S.: Antileukemic action of novel Pt(II) halogenido complexes: Comparison of the representative novel Pt(II) complex with the corresponding Pt(IV) complex, Chem. Biol. Drug. Des., 90, 2017, 262-271. 
  • Pantić, D.N.; Aranđelović, S.; Radulović, S.; Roller, A.; Arion, V.B.; Grgurić-Šipka, S: Synthesis, characterisation and cytotoxic activity of organoruthenium(II)-halido complexes with 1H-benzimidazole-2-carboxylic acid, J. Organomet. Chem., 819, 2016, 61-68. 
  • Nikolić, S.; Rangasamy, L.; Gligorijević, N.; Aranđelović, S.; Radulović, s.; Gasser, G.; Grgurić-Šipka, S:Synthesis, characterization and biological evaluation of novel ruthenium(II)-arene complexes containing intercalating ligands, J. Inorg. Biochem., 156, 2016, 156-165. 
  • Nikolić, S.; Opsenica, D.M.; Filipović, V.; Dojčinovič, B.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.: Strong in vitro Cytotoxic Potential of New Ruthenium-Cymene Complexes, Organometallics, 34, 2015, 3464-3473.
  • Marzo, T.; Savić, A.; Massai, L.; Michelucci, E.; Sabo, T.J.; Grgurić-Šipka, S.; Messori, L.: Reactions of Cytotoxic Metallodrugs with Lysozime in Pure DMSO explored through Uv-Vis Absorption Spectroscopy and ESI MS, Bioemetals, 28, 2015, 425-430.
  • Savić, A.; Filipović, L; Aranđelović, S.; Dojčinovič, B.; Radulović, S.; Sabo, T.J.; Grgurić-Šipka, S: Synthesis, characterization and cytotoxc activity of novel Pt(II) iododo complexes, Eur. J. Med. Chem. 82, 2014, 372-384.
  • Savić, A.; Misirlić-Denčić, S.; Dulović, M.; Mihajlović, Lj.E.; Jovanović, M.; Grgurić-Šipka, S.; Marković, I.; Sabo, T.J.: Synthesis, characterization and ROS-mediated cytotoxic action of novel (S,S)-1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid and corresponding esters, Bioorg. Chem. 54 (2014) 73-80.
  • Savić, A.; Baroud, A.A.; Grgurić-Šipka, S.: The new ruthenium(II)-bipyridyl complexes as potential PDT agent: Synthesis and characterization. Maced. J. Chem. Chem Eng. 33, (2014), 59-64.
  • Zmejkovski, B.B.; Savić, A.; Poljarević, J.; Pantelić, N.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.; Kaluđerović, G.N.; Sabo, T.J.: Synthesis characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R2edda-type esters, Polyhedron, (2014), 80, 106-111.
  • Ivanović, I.; Jovanović, K.K.; Gligorijević, N.; Radulović, S.; Arion, V.B.; Sheweshein, K.S.A.M.; Tešić, Ž.Lj.; Grgurić-Šipka, S: Ruthenium(II)-arene Complexes with Substitured Picolinato Ligands: Synthesis, Structure, Spectroscopic Properties and Antiproliferatice Activity. J. Organomet. Chem.  (2014), 749, 343-349.
  • Mojić, M.; Savić, A.; Arion, V.; Bulatović, M.; Poljarević, J.M.; Miljković, Dj.; Sabo, T.J.; Mijatović, S.; Maksimović-Ivanić, D.; Grgurić-Šipka, S.: Synthesis, X-ray structure and strong in vitro activity of novel organoruthenium complexes. J. Organomet. Chem. (2014), 749, 142-149.
  • Mihajlović, Lj.E.; Stanković, D.; Poljarević, J.; Manojlović, D.; Sabo, T.J.; Grgurić-Šipka, S.: Electrochemistry and bioactivity relationship of Pt(IV) complexes with cyclohexyl functionalized ethylenedimanine-N,N'-diacetate types of ligands. Int. J. Electrochem. Sci. (2013), 8, 8433-8441.
  • Ivanović, I.; Gligorijević, N.; Aranđelović, S.; Radulović, S; Roller, A.; Keppler, B.K.; Tešić, Ž. Lj.; Grgurić-Šipka, S.: New ruthenium(II) arene complexes bearing hydrazides or corresponding(thio)semicarbazones of 3- or 4-acetylpyridine: synthesis, characterization, crystal structure determination and antiproliferative activity. Polyhedron (2013), 61, 112-118.
  • Rakić, G.M.; Grgurić-Šipka, S.; Kaluđerović, G.N.; Bette, M.; Filipović, L.;Aranđelović, S.; Radulović,S.; Tešić,Ž.Lj.:The synthesis, spectroscopic, X-ray characterization and in vitro cytotoxic testing results of activity of five new trans-platinum(IV) complexes with functionalized pyridines. Eur. J. Med. Chem. (2012), 55, 214-219.
  • Misirlic Dencic, S.; Poljarevic, J.; Vilimanovich, U.; Bogdanovic, A.; Isakovic, A.J.; Stevovoc Kravic T.; Dulovic,; Zogovic, N.; Isakovic, A.M.; Grguric-Sipka, S,; Bumbasirevic V.; Sabo, T.; Trajkovic, V.; Markovic, I.: Cyclohexyl Analogues of Ethylenediamine Dipropanoic Acid Induce Caspase-Independent  Mitochondrial Apoptosis in Human Leukemic Cells. Chem. Res. Toxicol. (2012), 25, 931-939.
  • Mihajlović, Lj.E.; Savić, A.; Poljarević, J.; Vučković, I.; Mojić, M.; Bulatović, M.; Maksimović-Ivanić, D.; Mijatović, S.; Kaluđerović, G.N.; Stošić-Grujičić, S.; Miljković, Đ.; Grgurić-Šipka, S.; Sabo, T.J.: Novel methylene modified cyclohexyl ethylenediamine-N,N'-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. J. Inorg. Biochem. (2012), 109, 40-48.
  • Gligorijević, N.; Aranđelović, S.; Filipović, L.; Dojčinović, B.; Jakovljević, K.; Janković, R.; Grgurić-Šipka, S.; Ivanović, I.; Radulović, S.; Tešić, Ž,Lj.: Picolinate ruthenium(II)-arene complex with  in vitro antiproliferative and antimetastatic properties: Comparision to a series of ruthenium(II)-p-arene complexes with similar structure. J. Inorg. Biochem. (2012), 108, 53-61.
  • Miljković, Dj.; Poljarević, J.M.; Blaževski, J.; Petković, F.; Momčilović, M.; Nikolić, I.; Cvijetićanin, T.; Stošić-Grujičić, S.; Grgurić-Šipka, S.; Sabo, T.J. Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects. Eur. J. Med. Chem. (2012), 47, 194-201.
  • Rilak, A; Petrović B.; Grgurić-Šipka, S.; Tešić, Ž. Lj.; Bugarčić, Ž.: Kinetics and mechanism of the reactions of Ru(II)-arene complexes with some biologically relevant ligands. Polyhedron (2011), 30, 2339-2343.
  • Krstić, Milena; Sovilj, Sovilj P.; Grgurić­-Šipka, Sanja; Radosavljević Evans, Ivana; Borozan, Sunčica; Santibanez, Juan Francisco; Kocić, Jelena: New ruthenium(II) complexes with N-alkylphenothiazines: synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxycity. Eur. J. Med. Chem. (2010), 45, 3669-3676.
  • Grgurić-Šipka, Sanja; Ivanović, Ivanka;Rakić, Gordana.;Todorović, Nina; Gligorijević, Nevenka; Radulović, Siniša; Arion, Vladimir B.; Keppler, Bernhard K.;Tešić, Živoslav Lj.: Ruthenium(II) arene Complexes with Functionalized Pyridines: Synthesis, Characterization and Cytotoxic Activity. Eur. J. Med. Chem. (2010), 45, 1051-1058.
  • Grguric-Sipka, Sanja; Stepanenko, Iryna N.; Lazic, Jelena M.; Bartel, Caroline; Jakupec, Michael A.; Arion, Vladimir B.; Keppler, Bernhard K. Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin. Dalton Trans. (2009), 3334-3339.
  • Grgurić-Šipka, Sanja; Kowol, Christian R.; Valiahdi, Seied-Mojtaba; Eichinger, Rene; Jakupec, Michael A.; Roller, Alexander; Shova, Sergiu; Arion, Vladimir B.; Keppler, Bernhard K. Ruthenium(II) complexes of thiosemicarbazones: the first water-soluble complex with pH-dependent antiproliferative activity. Eur. J. Inorg. Chem. (2007), 2870-2878.