IHTM Department of
chemistry
Research
Still working
Institute of Chemistry, Technology and Metallurgy
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IHTM Department of
chemistry |
Still working |
Department of Chemistry is a part of Institute of Chemistry, Technology and Metallurgy |
 
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The focus of fundamental and applied research in organic synthesis is the design of new chemical reactions, and their application in total syntheses of complex organic compounds: natural products, pharmacologically significant compounds etc. Also, research directed to synthetic transformations of carbon C60, new, recently discovered allotropic modification of carbon, considered to find application in various aspects of advanced technologies in near future (organic superconductors, optical fibers, plastics with extraordinary properties etc.) has recently been initiated. |
 
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Development
of procedures for synthesis of steroid hormones and antihormones
Steroid hormones and antihormones have a very important role in
hormonal therapies of various diseases. Their synthesis is very
significant for pharmaceutical industry. We have used both
chemical synthesis and biotechnological techniques for the
development of an efficient procedure for preparation of estrone,
starting from diosgenin, and of mifepristone, starting from
estrone.
More will be added in the future...
Synthesis and activity study of new bioisosteric analogues of dopamine
Dopamine is an endogenous catecholamine with an important role in
regulation of functions of central nervous system, endocrine
system and peripheral nervous system. Disturbances of function of
the dopaminergic system is related to various pathological
states, such as: psychoses, schizophrenia, parkinsonism,
dependence disorders (alcoholism, drug abuse),
hypereprolactinemia and cardiovascular disorders. Chemical,
pharmacodynamic and pharmacokinetic properties of dopamine
prevent its direct use in therapy of such disorders. Therefore,
there is a great need for new substances that could regulate the
activity level of the dopaminergic system in the organism. Our
work encompasses synthesis and activity study of new dopaminergic
ligands whose structures are shown in the scheme. Some of them
have affinities of 1 to 10 nM, comparable to the most potent
dopaminergic ligands, It makes them possible candidates for new
pharmaceuticals. Pharmacological investigations of these
substances in vivo are under way.
