Course code:
422B2		 Course name:
Molecular Basis of Pathological Conditions

Academic year:

2024/2025.

Attendance requirements:

402B2 / 402B1

ECTS:

8

Study level:

basic academic studies

Study program:

Biochemistry: 4. year, summer semester, compulsory course

Teacher:

Marija Đ. Gavrović Jankulović, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

Jelica R. Milošević, Ph.D.
assistant with PhD, Faculty of Chemistry, Studentski trg 12-16, Beograd

Milena O. Zlatanova
research assistant, Faculty of Chemistry, Studentski trg 12-16, Beograd

Hours of instruction:

Weekly: four hours of lectures + four hours of labwork (4+0+4)

Goals:

The goal of this course is to broaden students’ knowledge of the pathological mechanisms responsible for the development of diseases. Students will study inborn and acquired disorders responsible for the development of diseases through examples. In order to help students understand the molecular basis of disorders, they will study the changes discovered at the molecular level (DNA, proteins) and at the cellular level, as well as the changes developed in tissues and in entire body.

Outcome:

To acquire comprehensive knowledge in the field of the molecular basis of pathological processes and the ability to carry out independent research.

Teaching methods:

Lectures, labwork, colloquia, seminars.

Extracurricular activities:

—

Coursebooks:

Main coursebooks:

  1. Carl A. Burtis, Edward R. Ashwood: Tietz Fundamentals of Clinical Chemistry, 5th Ed.
  2. William J. Marshall, Stephen K. Bangert: Clinical Chemistry, 5th Ed.
  3. Kumar Abbas, Fausto Aster: Pathologic Basis of Disease, 8th Ed., Saunders, Elsevier.

Supplementary coursebooks:

  • Selected review papers.

Additional material:

—

  Course activities and grading method

Lectures:

10 points (4 hours a week)

Syllabus:

  • Disorders of amino acid metabolism.
  • Disorders of plasma proteins.
  • Disorders of the carbohydrate metabolism.
  • Disorders of lipid and lipoproteins.
  • Disorders of Microelements.
  • Disorders of Vitamins.
  • Disorders of RBC and hemoglobin. Metabolism of porphyrins.
  • Disorders of the hepatobiliary system.
  • Disorders of the gastrointestinal system.
  • Electrolyte disturbances. Acid-base homeostasis.
  • Excretory system disorders.
  • Disorders of bone tissue.
  • Immune system disorders.
  • Enzymes in clinical diagnosis.
  • Oncology and tumor markers.
  • Acute and chronic inflammation.

Labwork:

15 points (4 hours a week)

Syllabus:

  • Disorders in metabolism of amino acid and protein.
  • Disorders in metabolism of carbohydrate (diabetes mellitus).
  • Disorders in metabolism of lipid (cardiovascular disease).
  • Disturbances in the metabolism of electrolytes and minerals (bone disease).
  • Disorders of the metabolic processes in the liver (hepatobiliary diseases).
  • Disorders of anabolism and catabolism of heme.
  • Nonprotein Nitrogen metabolites.
  • Enzymes in clinical diagnostics.

Semester papers:

10 points

Colloquia:

15 points

Oral exam:

50 points