Ljiljana I. Došen Mićović, Ph.D.

Personal data

Born: 1948, Belgrade, Yugoslavia.

Education and qualifications

1967-1971: Undergraduate studies - Physical chemistry / Prirodno-matematički fakultet (Belgrade, Serbia)

1973: Master of science studies - Physical chemistry / The University of Georgia (Athens, United States)

1979: Doctoral academic (PhD) studies - Chemistry / Prirodno-matematički fakultet (Belgrade, Serbia)

History of employment

1974: Assistant / Prirodno-matematički fakultet (Belgrade, Serbia)

1981: Scientific associate / Prirodno-matematički fakultet (Belgrade, Serbia)

1987: Assistant professor / Prirodno-matematički fakultet (Belgrade, Serbia)

1992: Assistant professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1995: Associate professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2005-2013: Full professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

Scientific interest

Computational chemistry, computational methods of medicinal chemistry and drug design, stereochemistry and conformational analysis of organic compounds, physical organic chemistry.

Other activities

Member of Serbian Chemical Society - Section for organic chemistry.

Representative references

Knjige i revijalni radovi / Books and reviews:

1. Lj.Došen-Mićović, Osnovi fizičke organske hemije i stereohemije, Zavod za udžbenike, Beograd, 2006.
2. Lj.Došen-Mićović, Molecular modeling of fentanyl analogs, J.Serb.Chem.Soc. ,69 (11) 843–853 (2004).
3. Lj.Došen-Mićović, Molecular Mechanics Treatment of Electrostatic and Solvation Effects on the Conformational Equilibria of Organic Compounds, J.Serb.Chem.Soc. 53(9), 455 (1988).

Izabrani radovi / Selected papers:

1.  “Fentanyl Analogs: Structure-Activity Relationship Study” S.Vuckovic, M.Prostran, M.Ivanovic,Lj.Dosen- icovic,Z.Todorovic,Z.Nesic,R.Stojanovic,N.Divac,Z.Mirkovic, Curr. Med.Chem., 16, 2467-2474 (2009). 

2. “Docking studies suggest ligand-specific δ-opioid receptor conformations” Vuk Micovic, Milovan D. Ivanovic, Ljiljana Dosen-Micovic, J.Mol.Model., 15 (3) 267-280 (2009).

3. "Steric interactions and the activity of fentanyl analogs at the μ-opioid receptor" Ljiljana Dosen-Micovic, Milovan Ivanovic and Vuk Micovic, Bioorganic & Medicinal Chemistry, 14 (9)2887-2895 (2006).

4. "The synthesis and preliminary pharmacological evaluation of racemic cis and trans 3-alkyl fentanyl analogues"; M.D. Ivanovic, I.V. Micovic, S. Vuckovic, M. Prostran, Z. Todorovic, V.D. Kricojevic, J.B. Djordjevic and Lj. Dosen-Micovic, J. Serb. Chem. Soc. 69 (7) 511 (2004).

5. "Stereoselective Free Radical Phenylsulfenylation of the Nonactivated delta-Carbon Atom", G.Petrovic, R.N.Saicic, Lj.Dosen-Micovic, Z. Cekovic, J.Serb.Chem.Soc., 69(10) 737 (2004).

6. “Neomycin Binding to Watson-Hoogsteen (W-H) DNA Triplex Groove: A Model”, Dev. P. Arya, Ljiljana Micovic, I. Charles, R. Lane Coffee, Jr., Bert Willis and Liang Xue, J. Am. Chem. Soc., 125 (13) 3733- 3744 (2003).

7. “An optimized synthesis of a key pharmaceutical intermediate methyl 4-(phenyl-propionyl-amino)-piperidine-4-carboxylate”, V. D. Kiricojevic, M. D. Ivanovic, I. V. Micovic,J. B. Djordjevic, G. M. Roglic and Lj. Dosen-Micovic, J. Serb. Chem. Soc., 67, (12) 793 (2002).

8. “The Synthesis and Preliminary Pharmacological Evaluation of 4-Methyl Fentanyl”, I. V.Micovic, M.D.Ivanovic, S.M.Vuckovic, Lj. Dosen – Micovic, V. Kiricojevic, Bioorg. Med. Chem. Lett., 10 (17), 2011-2014 (2000).

9. “3-Carbomethoxy Fentanyl: Synthesis, Pharmacology and Conformational Analysis”, I.V. Micovic, M.D. Ivanovic, S. Vuckovic, D. Jovanovic-Micic, D. Beleslin, Lj. Dosen-Micovic, V. Kiricojevic, Heterocyclic Communications, 4, 171 (1998).

10. "Searching Conformational Space with Molecular Mechanics Method. Dihedral Angle Random Increment Search", Lj.Dosen-Micovic, Tetrahedron, 51, 6789 (1995).