[dr Ljuba M. Mandic]

Phone:   011-3336676

Phone (local):   676

Office:   404

Laboratory:   403

E-mail:   ljmandic@chem.bg.ac.rs

Personal data

Born on April 27, 1953 in Donji Rajić, Croatia. Married. Speaks Serbian, English and Russian language.

Education and qualifications

1972-1976: Undergraduate studies - Chemistry / Prirodno-matematički fakultet (Belgrade, Serbia)

1977-1983: Master of science studies - Chemistry / Prirodno-matematički fakultet (Belgrade, Serbia)

1987-1992: Doctoral academic (PhD) studies - Chemistry / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

History of employment

1977: Graduate associate / Prirodno-matematički fakultet (Belgrade, Serbia)

1987: Assistant / Prirodno-matematički fakultet (Belgrade, Serbia)

1991: Assistant / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

1993: Assistant professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2003-2011: Associate professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

2011-2018: Full professor / University of Belgrade - Faculty of Chemistry (Belgrade, Serbia)

Scientific interest

Pathological and toxicological biochemistry, chemical education

Awards and merits

1997: Medal of Serbian Chemical Society

1997: Charter of Serbian Chemical Society

2004: Award of Ministry of science

Other activities

Member of Serbian Chemical Society. Member of presidency. Member of the administrative committee.

Member of Yugoslav Biochemical Society.

Member of Serbian society of toxicology.

Vice Dean of Academic Affairs from 2001 till 2002.

Deputy chairman of the Board of the Faculty of Chemistry from 2005 till 2006.

Head of the Department of Biochemistry from 2007 till September 30, 2013.

Participation in research projects

Finished projects:

  • 2010: Reinforcement of the Faculty of Chemistry, Uvinersity of Belgrade, towards becoming a centre of excellence in the region of West Balkans for molecular biotechnology and food research – FCUB-ERA 256716
    project type:   International
    project is funded by: European Union (Brusseles, Belgium)
  • 2011: Allergens, antibodies, enzymes and small physiologically relevant molecules: design, structure, function and significance – 172049
    project type:   National Fundamental Research Projects
    project is funded by: Ministry of Science and Technological Development (Belgrade, Serbia)

Author identification numbers

Representative references

Knjige i revijalni radovi / Books and reviews:

  1. Z. Maksimović, Lj. Mandić, J. Korolija, N. Smuđa: Zbirka pitanja i zadataka iz hemije - osnovni kurs, 4. izdanje, Građevinska knjiga, Beograd 2004, 220 str.
  2. Lj. Mandić, J. Korolija, D. Danilović: Udžbenik - Hemija za VII razred, Zavod za izdavanje udžbenika i nastavna sredstva, Beograd 1992, 136 str.
  3. Lj. Mandić, J. Korolija, D. Danilović: Udžbenik - Hemija za VIII razred, Zavod za izdavanje udžbenika i nastavna sredstva, Beograd 1993, 127 str.
  4. Lj. Mandić, J. Korolija, D. Danilović: Zbirka zadataka sa laboratorijskim vežbama iz hemije za VII razred osnovne škole, Zavod za izdavanje udžbenika i nastavna sredstva, Beograd 1992, 53 str.
  5. Lj. Mandić, J. Korolija, D. Danilović: Zbirka zadataka sa laboratorijskim vežbama iz hemije za VIII razred osnovne škole, Zavod za izdavanje udžbenika i nastavna sredstva, Beograd 1993, 79 str.
  6. J. Korolija, D. Danilović, Lj. Mandić: Hemija+ - zbirka takmičarskih zadataka za osnovnu školu, Studentski trg, Beograd 1995, 58 str.
  7. J. Korolija, Lj. Mandić, Lj. Solujić, D. Trivić: Zbirka zadataka za prijemne ispite iz hemije, Studentski trg, Beograd 1996.
  8. Lj. Mandić, J. Korolija, D. Danilović: Udžbenik - Hemija za VII razred, Zavod za udžbenike i nastavna sredstva, Srpsko Sarajevo 2001, 174 str.
  9. Lj. Mandić, J. Korolija, D. Danilović: Udžbenik - Hemija za VIII razred, Zavod za udžbenike i nastavna sredstva, Srpsko Sarajevo 2001, 139 str.
  10. J. Korolija, D. Danilović, Lj. Mandić: Zbirka takmičarskih zadataka, NNK Internacional, Beograd 2002, 120 str.
  11. Lj. Mandić, J. Korolija, D. Danilović: Hemija za 7. razred osnovne škole - udžbenik, Zavod za udžbenike i nastavna sredstva, Beograd 2003, prvo izdanje, 179 str.
  12. Lj. Mandić, J. Korolija, D. Danilović: Zbirka zadataka iz hemije sa laboratorijskim vežbama za 7. razred osnovne škole, Zavod za udžbenike i nastavna sredstva, Beograd 2003, prvo izdanje, 81 str.
  13. J. Korolija, Lj. Mandić: Hemija: Priručnik za nastavnike za 7. razred osnovne škole, Zavod za udžbenike i nastavna sredstva, Beograd 2004, prvo izdanje, 167 str.
  14. J. Korolija, D. Danilović, Lj. Mandić: Hemija - zbirka takmičarskih zadataka, prerađeno i dopunjeno izdanje, NNK Internacional, Beograd 2005, 168 str.
  15. Lj. Mandić, J. Korolija, D. Danilović: Hemija za 8. razred osnovne škole - udžbenik, Zavod za udžbenike i nastavna sredstva, prvo izdanje, Beograd 2005, 163 str.
  16. Lj. Mandić, J. Korolija, D. Danilović: Zbirka zadataka sa laboratorijskim vežbama iz hemije za 8. razred osnovne škole, Zavod za udžbenike i nastavna sredstva, prvo izdanje, Beograd 2005, 55 str.

Izabrani radovi / Selected papers:

  1. I.D. Pavićević, V.B. Jovanović, M.M. Takić, A.Z. Penezić-Romanjuk, J.M. Aćimović, Lj.M. Mandić: Fatty acids binding to human serum albumin: changes of reactivity and glycation level of Cysteine-34 free thiol group with methylglyoxal. Chemico-Biological Interactions (2014)  224, 42–50.
  2. V.B. Jovanović,  I.D. Pavićević,  M.M. Takić, A.Z. Penezić-Romanjuk, , J.M. Aćimović, Lj.M. Mandić: The influence of fatty acids on determination of human serum albumin thiol group, Analytical Biochemistry (2014) 448, 50-57.
  3. Jelena M. Aćimović; Ana Penezić-Romanjuk, Ivan D. Pavićević Vesna B. Jovanović and Ljuba M. Mandić: The efficiency of compounds with α-amino-β-mercapto-ethane group in protection of human serum albumin carbonylation and cross-linking with methylglyoxal, Mol. BioSyst. (2014) 10 (8), 2166 - 2175. 
  4. Maja D. Vitorović-Todorović, Catherine Koukoulitsa, Ivan O. Juranić, Ljuba M. Mandić, Branko J. Drakulić. Structural modifications of 4-aryl-4-oxo-2-aminylbutyramides and their acetyl- and butyrylcholinesterase inhibitory activity. Investigation of AChE-ligand interactions by docking calculations and molecular dynamics simulations. European Journal of Medicinal Chemistry (2014), 81, 158-175.
  5. Vesna B. Jovanović, Jelena M. Aćimović, Vesna S. Dimitrijević-Srecković, Ljuba  M. Mandić. How the sialylation level of serum N-acetyl--D-glucosaminidase A form in Type 1 diabetes mellitus influences its activity? J. Serb. Chem. Soc. (2014) 79/12, 1491-1503.
  6. V.B. Jovanović, A.Z. Penezić-Romanjuk, I.D. Pavićević, J.M. Aćimović, Lj.M. Mandić: Improving the reliability of human serum albumin-thiol group determination, Analytical Biochemistry (2013) 439, 17–22.
  7. Jelena M. Acimovic; Vesna B. Jovanovic; Vesna Dimitrijevic Sreckovic; Ana Penezic-Romanjuk and Ljuba M. Mandic. Monitoring of the human serum albumin carbonylation level through determination of guanidino group content. Analytical Biochemistry (2013), 433, 162-167
  8. Tamara Popović, Suncica Borozan, Ljuba Mandić, Aleksandra Arsić, Jasmina Debeljak Martačić, Vesna Vučić, Aleksandar Trbović, Marija Glibetić: Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male Wistar rats. Journal of Animal Physiology and Animal Nutrition (2012), 96, 1020-102
  9. Filipović, D., Zlatković, J., Pavićević, I., Mandić, L. & Demajo, M. Chronic isolation stress compromises JNK/c-Jun signaling in rat brain. Journal of Neural Transmission (2012), 119 (11), 1275-1284
  10. Jasminka N. Korolija, Jovica V. Plavsic, Dragan Marinkovic, and Ljuba M. Mandic. Beer as a Teaching Aid in the Classroom and Laboratory. Journal of Chemical Education (2012), 89(5), 605-609
  11.  Vesna P. Stankov-Jovanović, Violeta D. Mitić, Marija D. Ilić, Ljuba M.Mandić, Snežana D. Nikolić-Mandić, Enzymatic kinetic method for determination of  propranolol  hydrochloride  in  pharmaceuticals  based  on  its  inhibitory  effect  on cholinesterase. Hemijska industrija (2012), 66 (5), 677-684  
  12.   Jelena M. Acimovic; Vesna B. Jovanovic; Milica R. Veselinovic; Vesna Dimitrijevic Sreckovic; Ljuba M. Mandic. Method for monitoring of the protein amino group changes during carbonylation. Clin Biochem  (2011) 44, 994-999
  13. Acimović M.Jelena, Stanimirović D.Bojana, Todorović Nina, Jovanović B.Vesna, Mandić M.Ljuba. Influence of the microenvironment of thiol groups in low molecular mass thiols and serum albumin on the reaction with methylglyoxal, Chemico-Biological Interactions(2010), 188, 21-30
  14. Vitorovic-Todorovic, Maja D.; Juranic, Ivan O.; Mandic, Ljuba M.; Drakulic, Branko J. 4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields. Bioorganic & Medicinal Chemistry (2010), 18 (3):1181-1193
  15. Filipović Dragana, Mandić Ljuba, Kanazir Dušan, Pajović Snežana. Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver, Molecular and Cellular Biochemistry (2010), 338:167–174 
  16. Takic M., Ristic-Medic D., Mandic Lj., Glibetic M., Arsic A., Debeljak-Martacic J., Ristic-Oddiano G. N-3 polyunsaturated acids in erythrocyte phospholipids are associated with insulin sensitivity in obese patients on a typical Serbian diet. Archives of biological sciences (2009), 61 (1), 37-43
  17. Aćimović Jelena, Stanimirović Bojana, Mandić M. Ljuba: The role of thiol group in protein modification with methylglyoxal. Journal of Serbian Chemical Society (2009), 74 (8-9), 867-883
  18. Jovanović V. B., Dimitrijević-Srecković V. S., Mandić Lj.  M.. Serum N-acetyl-b-D-glucosaminidase profiles in type 1 diabetes secondary complications: causes of changes and significance of determination. Journal of Clinical Laboratory Analysis (2008), 22, 307-313
  19. Stankov-Jovanović, Vesna P.; Nikolić-Mandić, Snežana D.; Mandić, Ljuba M.; Mitić, Violeta D. A modification of the kinetic determination of pancuronium bromide based on its inhibitory effect on cholinesterase. Journal of Clinical Laboratory Analysis (2007), 21(2), 124-131.
  20. Stankov-Jovanović, Vesna P.; Nikolić-Mandić, Snežana D.; Mandić, Ljuba M.; Mitić, Violeta D. Cholinesterase inhibition based determination of pancuronium bromide in biological samples. Analytical and Bioanalytical Chemistry (2006), 385(8), 1462-1469.
  21. Aćimović, Jelena M.; Jovanović, Vesna B.; Mandić, Ljuba M. Influence of pigments and pH of urine on the determination of N-acetyl-beta-D-glucosaminidase activity with 2-methoxy-4-(2'-nitrovinyl)-phenyl-N-acetyl-beta-D-glucosaminide. Journal of Clinical Laboratory Analysis (2005), 19(6), 260-266.
  22. Rančić, Sofija M.; Nikolić-Mandić, Snežana D.; Mandić, Ljuba M. Kinetic spectrophotometric method for gold(III) determination. Analytica Chimica Acta (2005), 547(1), 144-149.
  23. Mandić, Ljuba M.; Aćimović, Jelena M.; Jovanović, Vesna B. The possibility of determining N-acetyl-beta -D-glucosaminidase isoenzymes under alkaline conditions. Clinical Biochemistry (2005), 38(4), 384-389.
  24. Maksimović, Radmila; Mandić, Ljuba; Spasić, Slavica: The basic hematological measurements in peripheral blood from workers exposed to mercury vapours. Jugoslav Med. Biohem (2004), 23, 381-385.
  25. Mandić, Ljuba; Radmila, Maksimović; Jelena, Acimović; Dubravka, Dobrić. Change in the isoenzyme profiles of urinary N-acetyl-beta-D-glucosoaminidase in workers exposed to mercury. Toxicology and Industrial Health (2002), 18(5), 207-214.
  26. Tasić, Jelena; Ristić, Slavica; Piperski, Vesna; Dačević, Mirjana; Pejanović, Vjera; Jokanović, Milan; Mandić, Ljuba. Simultaneous LC determination of tiazofurin, its acetyl and benzoyl esters and their active metabolite thiazole-4-carboxamide adenine dinucleotide in biological samples. Journal of Pharmaceutical and Biomedical Analysis (2002), 30(4), 993-999.
  27. Ćirković, Tanja D.; Gavrović-Jankulović, Marija Dj.; Bukilica, Mirjana N.; Mandić, Ljuba; Petrović, Spomenka Z.; Jankov, Ratko M. Isolation and partial characterization of an acid phosphatase from Artemisia vulgaris pollen extract. Journal of the Serbian Chemical Society (2002), 67(8-9), 567-572.
  28. Mandic, Ljuba: N-acetyl-beta -D-glucosaminidase in diabetes, Medical investigations, (2001),35/1, 38-45.
  29. Mandic, Ljuba; Stojanovic, Srdan; Colovic, Ana; Milin, Nenad. Determination of serum glycosylated proteins: Comparison of methods with thiobarbituric acid and phenol-sulfuric acid. Jugoslovenska Medicinska Biohemija (2000), 19(4), 411-415.
  30. Igor Matijašević, Jasminka Korolija, Ljuba M. Mandić. The evaluation of combinatorial abilities of high school students in the context of chemistry. Journal of Science Education  (2012), 13 (2) 60-63
  31. J. Korolija, M. Randjelović, S. Nikolic-Mandić, V. D. Krsmanovic, Lj. M. Mandic: Training of university students for successful problem creating. Journal of Science Education (2007), 8 (N1), 10-13.
  32. Jasminka Korolija, Gordana Jović, Ljuba Mandić: "Presentation and consolidation of physical and chemical changes of substances through pupils active work". Journal of Science Education (2005), 6(2), 76-79.
  33. Lj. Mandić, J. Korolija, B. Steljić, D. Danilović, V. Krsmanović: "Secret concept"-problems for knowledge testing by computer, J. of Sicence Education (2002), 3(1), 41-43.